Irvingia gabonensis (Aubry-Leconte ex O´rorke) Baill


An evergreen tree that reaches 25-40 m in height and grows in tropical Africa. The trunk is straight up to more than 2 m in circumference; it has buttresses at 3 m in height. The lateral branches are leafy and ascending, making the crown dense and spherical. It has a fruit known as African mango.

Part used

The fruits are used.

Active principles

  • Water: 84 %.
  • Vitamins: its high content in beta-carotene, folic acid and vitamin C is highlighted. There are also vitamins B1, B2, B3, B5, B6, E and K.
  • Minerals: calcium, magnesium, potassium, iron, iodine.
  • Polysaccharides of mucilaginous type (soluble fiber), 12.8 g %.
  • Proteins: 0.63 g %.
  • Lipids (0.45 g %): saturated and unsaturated fatty acids.
  • Flavonoids: quercetin, kaempferol.
  • Phenolic acids: ellagic, malic, myristic, p-coumaric.

Pharmacological action

An extract is obtained from mango seeds, marketed as IGOB131R, with which studies have been carried out that have demonstrated the following actions:

  • Decreases insulin and leptin resistance.
  • Inhibits lipogenesis (synthesis of triglycerides, which are the reserve fats).
  • Promotes lipolysis (destruction of reserve fats).
  • Stimulates thermogenesis.
  • Satiating.


Adjuvant in weight control treatments.


  • Pregnancy and lactation. There is no information on the safety of IGOB131R extract.
  • Allergy to the plant.



Drug interactions

  • No interactions have been described for the extract IGOB131R.
  • The pulp of the fruit, due to its mucilage content, could interfere with the absorption of medicines, so it is recommended to distance the intake of medicines.

Side effects

May cause slight headache and insomnia.


-.Ngondi, J.L., Oben, J.E., Minka, S.R. The effect of Irvingia gabonensis seeds on body weight and blood lipids of obese subjects in Cameroon. Lipids in Health and Disease 2005, 

-.Oben, J.E., Ngondi, J.L., Blum, K. Inhibition of Irvingia gabonensis seed extract (OB131) on adipogenesis as mediated via down regulation of the PPARgamma and Leptin genes and up-regulation of the adiponectin gene. Lipids in Health and Disease 2008, 

-.Judith L Ngondi1, Blanche C Etoundi1, Christine B Nyangono1, Carl MF Mbofung2 and Julius E Oben1.IGOB131, a novel seed extract of the West African plant Irvingia gabonensis, significantly reduces body weight and improves metabolic parameters in overweight humans in a randomized double-blind placebo controlled investigation. Lipids in Health and Disease2009

-.Ross SM. African mango a proprietary seed extract of Irvingia gabonensis is found ti by effective in reducing body weight and improving metabolic parameters in overweight humans. Holist Nurs Pract. 2011 Jul-Aug;25(4):215-7.

-.Onakpoya I, Davies L, Posadzki P, Ernst E. The efficacy of Irvingia gabonensis supplementation in the management of overweight and obesity: a systematic review of randomized controlled trials. J Diet Suppl. 2013 Mar;10(1):29-38.

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