Determination of the antitumor properties of the product CTP in combination with Vitamin C in KRAS mutations in human cancer (CTPC)
The main objective of this project is the determination of the antitumor and anti-inflammatory properties of the product CTP of Soria Natural in combination with vitamin C. The project focused on the study of four chemoresistant tumor cell lines, two of colorectal cancer and two of pancreatic adenocarcinoma, with mutation in the KRAS gene.
The results show that all four lines are sensitive to the compounds. A dose-dependent proapoptotic effect and a cytostatic effect, as well as an anti-inflammatory effect on cells of the immune system, have been demonstrated. Finally, it has been determined which genes are altered by both compounds, as well as the pathways through which they exert their antitumor action.
The project, which has lasted three years, was carried out in collaboration with the Jiménez Díaz Foundation and received support from the Center of Development of Industrial Technology (CDTI) of the Ministry of Science and Innovation, co-financed by the European Regional Development Fund (ERDF).